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Pantheon Peptides
Brain & Nerve4 cited studies

Semax

ACTH(4-10) analog — nootropic peptide for cognition, focus, and neuroprotection.

SummaryMechanismDosingSafetyStudies
Research use only — not for human consumption.

What it is

Semax is a Russian-developed nootropic peptide based on the ACTH(4-10) sequence. It enhances memory, learning, and mood by raising BDNF and modulating dopaminergic and serotonergic pathways. It also stimulates the brain's default-mode network and offers neuroprotective effects through improved blood flow, mitochondrial stability, and cerebral resilience after ischemic insult.

Mechanism of action

Heptapeptide analog of the N-terminal ACTH(4-10) fragment. Increases BDNF and NGF expression, modulates monoaminergic neurotransmission, and influences immune/vascular gene expression in ischemic brain regions.

Half-life: Not established in the published literature. Intranasal tritiated Semax reaches rat brain within two minutes, mostly intact (Shevchenko 2006), which measures penetration rather than a half-life.

Evidence summary

Approved in Russia for stroke and cognitive disorders. Mechanistic studies show antioxidant action, default-mode network modulation, and post-ischemic gene expression effects supporting neuroprotection.

Pantheon dosing guide

Application
Subcutaneous injection.
BAC Water
3 mL
Dose
6 units (200 mcg).
Frequency & Cycle Length
5 days on / 2 days off. 6 weeks.
Timing
Patient Preference.
Key Benefits
Enhances cognitive function and memory (Nootropic). Supports neuroprotection and brain repair. Enhances attention, mental clarity, and motivation. Improves mental resilience.

Additional research protocol context

The printed guide above is Pantheon's dosing reference. These broader research examples are provided as context and may use different schedules.

  • 0.1% nasal spray: 1–2 sprays per nostril, 2–3× daily
  • Subcutaneous: 250–1,000 mcg daily, 4-week cycles
  • Cycle off for 4 weeks between courses

Side effects & safety

  • Generally well-tolerated
  • Mild irritability or headache reported
  • Long-term Western safety data is limited

Cited studies

  1. Shevchenko KV, Nagaev IY, Andreeva LA, et al. (2006). Kinetics of Semax penetration into the brain and blood of rats after its intranasal administration. Bioorganicheskaia Khimiia.
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  2. (2024). Semax exhibits antioxidant properties that help protect neurons from oxidative stress. Synapse Drug Intelligence.
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  3. (2018). Effects of Semax on the Default Mode Network of the Brain. NeuroImage / NLM.
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  4. (2014). The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia. Doklady Biochemistry and Biophysics (NLM).
    Read source ↗
Disclaimer

All content is for research and educational purposes. Peptides described are sold for laboratory research use only and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before beginning any protocol.