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Selank

Heptapeptide derived from tuftsin — anxiolytic and cognitive support without sedation.

SummaryMechanismDosingSafetyStudies
Research use only — not for human consumption.

What it is

Selank is a synthetic peptide derived from the immunomodulatory peptide tuftsin, developed in Russia for anti-anxiety and cognitive applications. It promotes relaxation and mental clarity without the sedation typical of benzodiazepines. Reported benefits include reduced stress, better focus and memory, immune modulation, and improved sleep quality in anxiety-driven insomnia.

Mechanism of action

Modulates GABAergic and serotonergic neurotransmission, inhibits enkephalin-degrading enzymes (extending endogenous opioid signalling), and influences expression of genes related to stress and immune response. Cytokine modulation contributes to its dual psycho-immunological profile.

Half-life: Short — minutes; intranasal delivery used for repeat daily dosing.

Evidence summary

Russian clinical work in generalized anxiety and asthenic disorders demonstrates anxiolytic effect comparable to medazepam without sedation. Mechanistic work supports GABAergic modulation and enkephalin-system effects.

Typical dosing protocols

Typical dose
250–750 mcg
Frequency
Once daily
Cycle length
4 weeks
  • 0.15% nasal spray: 1–2 sprays per nostril, 2–3× daily
  • Subcutaneous: 250–750 mcg daily, 4-week cycles
  • Often used short-term during high-stress periods

Side effects & safety

  • Mild headache or fatigue at higher doses
  • Rare nasal irritation with intranasal use
  • Long-term Western safety data is limited

Cited studies

  1. (2016). Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Frontiers in Pharmacology (NLM).
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  2. (2018). The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. Russian Journal of Bioorganic Chemistry (NLM).
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  3. (2008). Immunomodulatory effects of selank in patients with anxiety-asthenic disorders. Zhurnal Nevrologii i Psikhiatrii (NLM).
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Disclaimer

All content is for research and educational purposes. Peptides described are sold for laboratory research use only and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before beginning any protocol.