What it is
5-Amino-1MQ is a small molecule that inhibits the enzyme NNMT (nicotinamide N-methyltransferase), a regulator of energy metabolism and adipose biology. By blocking NNMT, 5-Amino-1MQ encourages fat burning while supporting lean muscle preservation. It may also improve cellular energy availability and insulin sensitivity, contributing to balanced blood sugar and reduced metabolic disorder risk.
Mechanism of action
NNMT consumes SAM and converts nicotinamide to 1-methylnicotinamide. Inhibiting NNMT raises intracellular SAM and NAD+ pools, improving energy substrate handling and reducing white-adipose lipid storage in preclinical models.
Half-life: Short โ typical oral half-life is several hours; daily dosing is standard.
Evidence summary
Preclinical mouse data (Neelakantan 2017) showed reversal of high-fat-diet-induced obesity. Subsequent reviews summarise NNMT's role in obesity, type 2 diabetes, and obesity-linked osteoarthritis. Human trials are early.
Typical dosing protocols
- 50โ150 mg orally, once daily
- 8โ12 week cycles common
- Stack with cardio + resistance training for best body-composition effect
Side effects & safety
- Generally well-tolerated in published preclinical work
- Possible mild GI upset on initiation
- No long-term human safety data
Cited studies
- Neelakantan H, Vance V, Wang HL, et al. (2017). Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology (NLM).Read source โ
- (2021). Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes. International Journal of Molecular Sciences (NLM).Read source โ
- (2016). Discovery of Novel N-Nicotinamide Methyltransferase Inhibitors to Combat Obesity-Linked Osteoarthritis. Defense Technical Information Center.Read source โ
All content is for research and educational purposes. Peptides described are sold for laboratory research use only and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before beginning any protocol.