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Pantheon Peptides
Anti-Aging4 cited studies

NAD+

Essential coenzyme for cellular energy, sirtuin activity, and DNA repair — central to longevity research.

Also known as: NAD · Nicotinamide Adenine Dinucleotide
SummaryMechanismDosingSafetyStudies
Research use only — not for human consumption.

What it is

NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme that supports cellular energy production and mitochondrial function. It powers redox metabolism, sirtuin and PARP signalling, and DNA repair processes. Tissue NAD+ levels decline with age — supplementation strategies aim to restore baseline and support energy, focus, and cellular resilience.

Mechanism of action

NAD+/NADH redox couple is central to glycolysis, the TCA cycle, and oxidative phosphorylation. NAD+ is a substrate for sirtuins (SIRT1–7), PARPs, and CD38, linking it to chromatin regulation, DNA damage response, and circadian / metabolic biology.

Half-life: Short — minutes once delivered; precursors (NMN, NR) and IV NAD+ extend systemic exposure differently.

Evidence summary

Strong preclinical case for NAD+ supplementation in aging, neurodegeneration, and metabolic disease. Human precursor trials show modest but real biomarker improvements; large outcome trials are still emerging.

Pantheon dosing guide

Application
Subcutaneous Injection.
BAC Water
4 mL.
Dose
40 units (50 mg).
Frequency & Cycle Length
Once every 3rd day. 4 weeks.
Timing
Take in the morning on an empty stomach, at least 30 minutes before eating.
Key Benefits
NAD+ is an essential coenzyme that supports cellular energy production and mitochondrial function to promote vitality, recovery, and healthy aging.

Additional research protocol context

The printed guide above is Pantheon's dosing reference. These broader research examples are provided as context and may use different schedules.

  • Subcutaneous: 50–250 mg daily, titrate to flush tolerance
  • IV: 250–1,000 mg infused over 2–4 hours, weekly to monthly
  • Pair with NAD+ precursors (NMN, NR) and exercise

Side effects & safety

  • Flushing, chest pressure, nausea on rapid IV infusion — slow the rate
  • Mild fatigue or vivid dreams reported anecdotally
  • Methyl-donor depletion concern with chronic high doses — pair with B-vitamins

Cited studies

  1. (2019). NAD+ in Aging and Disease. Cell.
    Read source ↗
  2. (2018). NAD+ in aging, metabolism, and neurodegeneration. Science.
    Read source ↗
  3. (2022). NAD+ precursor supplementation in human ageing. GeroScience.
    Read source ↗
  4. (2020). The therapeutic perspective of NAD+ precursors in age-related diseases. Biochemical and Biophysical Research Communications.
    Read source ↗
Disclaimer

All content is for research and educational purposes. Peptides described are sold for laboratory research use only and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before beginning any protocol.