Peptides for Sleep

Primary Benefits

Epithalon

• Stimulates melatonin release from the pineal gland, improving circadian rhythm regulation
• Reported to enhance deep and restorative sleep in clinical studies
• Supports telomere health and healthy aging, indirectly benefiting sleep cycles

Selank

• An anxiolytic peptide that reduces cortisol and calms the nervous system
• Improves sleep onset and maintenance, especially in anxiety-related insomnia
• Enhances serotonin and dopamine balance, leading to more stable mood and rest

Semax

• Primarily studied for cognitive enhancement, but reports show improved mental calmness at lower dosing
• Reduces neuroinflammation and hyperarousal, which can interfere with sleep
• Indirectly supports better sleep in individuals with stress-related disturbances

Sermorelin, CJC-1295, Ipamorelin

• All three stimulate natural growth hormone (GH) release, which peaks during slow-wave sleep
• Users report deeper, more restorative sleep and vivid dreams
• Improve overnight tissue repair and recovery, leading to better energy on waking

MK-677 (Oral)

• A non-peptide GH secretagogue studied for improving sleep quality and dream vividness
• Supports GH and IGF-1 release without injections
• Often reported to improve REM and deep sleep cycles

Potential Side Effects

• Epithalon: Rare injection site irritation; otherwise well-tolerated
• Selank: Mild headache or nasal irritation if administered intranasally (in some studies); injections well-tolerated
• Semax: Overstimulation or anxiety at higher doses
• Sermorelin / CJC-1295 / Ipamorelin: Redness at injection site; vivid dreams; temporary water retention
• MK-677: Increased appetite, mild edema, occasional fatigue if overdosed

Dosing & Protocol

Epithalon – 10mg (Subcutaneous, SQ)

• Reconstitution: 1.0 ml bacteriostatic water
• Daily Dose: 10 mg (100 units)
• Cycle: Every 3 days for 15 days; repeat twice yearly (5 vials total)
• Timing: Morning, on an empty stomach

Selank – 5mg (SQ)

• Reconstitution: 3.0 ml bacteriostatic water
• Daily Dose: 100 mcg (6 units)
• Cycle: 5 days on / 2 days off, 6 weeks
• Timing: Based on personal preference

Semax – 10mg (SQ)

• Reconstitution: 3.0 ml bacteriostatic water
• Daily Dose: 166 mcg (6 units)
• Cycle: 5 days on / 2 days off, 6 weeks
• Timing: Based on personal preference

Sermorelin – 2mg / 5mg (SQ)

• Reconstitution:
   – 2 mg vial → 2.0 ml bacteriostatic water
   – 5 mg vial → 2.5 ml bacteriostatic water
• Daily Dose:
   – 2 mg → 100–200 mcg (10–20 units)
   – 5 mg → 200–400 mcg (10–20 units)
• Cycle: 5 days on / 2 days off, 4–5 weeks
• Timing: Morning, 2 hours after eating, or before bed

CJC-1295 (no DAC) – 2mg (SQ)

• Reconstitution: 2.0 ml bacteriostatic water
• Daily Dose: 100–200 mcg (10–20 units)
• Cycle: 5 days on / 2 days off, 4–12 weeks
• Timing: 2 hours after last meal, just before bed

Ipamorelin – 2mg / 5mg (SQ)

• Reconstitution:
   – 2 mg → 2.0 ml bacteriostatic water
   – 5 mg → 2.5 ml bacteriostatic water
• Daily Dose:
   – 2 mg → 100–200 mcg (10–20 units)
   – 5 mg → 200 mcg (10 units)
• Cycle: 5 days on / 2 days off, 4–5 weeks
• Timing: Before bedtime on empty stomach

MK-677 – Oral

• Form: 15 mg × 60 caps (900 mg total)
• Daily Dose: 15–30 mg (1–2 caps)
• Cycle: 10–12 weeks
• Timing: On an empty stomach

Who Are These For?

• Individuals struggling with insomnia or irregular sleep cycles
• Those experiencing anxiety-driven sleep disruption
• Athletes or high performers seeking deep recovery and GH optimization
• Older adults with declining melatonin or GH levels
• People needing circadian rhythm reset (e.g., shift work, jet lag)

Notes

• Epithalon and Selank are most direct for circadian and anxiety-related sleep issues
• Sermorelin, CJC-1295, and Ipamorelin improve deep-wave, recovery-driven sleep
• MK-677 offers a non-injectable option for those preferring oral delivery
• Stacking (e.g., Selank + Ipamorelin) can be more effective than a single peptide

Disclaimer

The information provided is for educational purposes only and does not substitute medical advice. Always consult a qualified healthcare professional before starting any peptide protocol.