What it is
GHRP-2 is a synthetic peptide designed to stimulate the body's natural production of growth hormone, often used in research for performance, recovery, and body composition contexts. It enhances GH pulse amplitude, supports lean tissue, accelerates recovery, and improves sleep and immune function.
Mechanism of action
Agonist at the growth hormone secretagogue receptor (GHSR-1a / ghrelin receptor) on pituitary and hypothalamic neurons. Drives strong GH release; minor cortisol and prolactin elevation possible at higher doses (greater than ipamorelin).
Half-life: ~15โ60 minutes.
Evidence summary
Established as a strong GH secretagogue in healthy adults and GH-deficient pediatric populations. Pharmacology and dose-response work characterised in the Bowers / Bowers-Howard line of research; food-animal data confirms growth-promoting effect.
Typical dosing protocols
- 100โ300 mcg subcutaneous, 2โ3ร daily
- Often paired with CJC-1295 for amplified GH pulse
- 12-week cycles, with periodic IGF-1 monitoring
Side effects & safety
- Increased appetite (ghrelin agonism)
- Mild cortisol or prolactin elevation possible
- Injection-site irritation
Cited studies
- (2024). Robust growth hormone responses to GH-releasing peptide 2 in adolescents. Journal of Pediatric Endocrinology and Metabolism (PubMed).Read source โ
- (2001). Growth hormone-releasing peptide-2 stimulates GH secretion in GH-deficient patients with mutated GH-releasing hormone receptor. Journal of Clinical Endocrinology & Metabolism.Read source โ
- (1996). GHRP-2, GHRH and SRIF interrelationships during chronic administration of GHRP-2 to humans. Journal of Pediatric Endocrinology and Metabolism.Read source โ
- (2000). The effects of growth hormone-releasing peptide-2 (GHRP-2) on the release of growth hormone and growth performance in swine. Domestic Animal Endocrinology.Read source โ
- (2004). Pharmacological characteristics of KP-102 (GHRP-2), a potent growth hormone-releasing peptide. Arzneimittelforschung.Read source โ
All content is for research and educational purposes. Peptides described are sold for laboratory research use only and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before beginning any protocol.