BPC-157 — Reference, Dosing & Cited Studies

What it is

BPC-157 (Body Protection Compound 157) is a synthetic pentadecapeptide with sequence GEPPPGKPADDAGLV, derived from a naturally occurring protein in gastric juice. Known for its powerful healing properties, BPC-157 promotes tissue repair, making it popular for injury recovery in muscles, tendons, and ligaments. It also supports gut health by reducing inflammation, healing ulcers, and promoting digestive tract repair. Studies suggest BPC-157 enhances blood flow to damaged tissues, accelerating recovery from injuries and surgeries.

Mechanism of action

BPC-157 appears to upregulate growth hormone receptor expression, promote angiogenesis (VEGF pathway), modulate the nitric oxide system, and interact with dopaminergic, serotonergic, and GABAergic systems. Its pleiotropic action may explain its broad tissue-healing profile.

Half-life: Short (minutes in plasma); oral bioavailability is low, most clinical data use injection.

Evidence summary

Extensive rodent data demonstrates accelerated tendon-to-bone healing, ligament repair, and gut mucosal protection. Human data is limited — most evidence is preclinical or anecdotal. No FDA-approved indication exists.

Typical dosing protocols

Typical dose

250–500 mcg

Frequency

Once daily

Cycle length

8 weeks

Localized injury (tendon, joint): 250 mcg subcutaneous near the site, once or twice daily, 4–8 weeks
Systemic recovery or GI issues: 250–500 mcg subcutaneous, once daily, 4–8 weeks
Often stacked with TB-500 for chronic injury (Wolverine protocol)

Side effects & safety

Generally well-tolerated in rodent studies and anecdotal human use
Mild injection-site irritation possible
No published long-term human safety data

Cited studies

Disclaimer

All content is for research and educational purposes. Peptides described are sold for laboratory research use only and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before beginning any protocol.