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Pantheon Peptides
Peptides for Specific Conditions

Peptides That Support Nitric Oxide (NO)

Updated April 28, 2026

Epithalon – 10mg

Benefits & Mechanism:
Epithalon helps restore hormonal and circadian balance, indirectly supporting nitric oxide by reducing oxidative stress and improving endothelial function. Some studies suggest it enhances endothelial nitric oxide synthase (eNOS) activity, which helps maintain vascular tone and circulation.

Dosing & Protocol:

  • Reconstitution: 1 ml bacteriostatic water
  • Daily Dose: 10 mg (100 units)
  • Cycle: Every 3 days for 15 days; repeat twice yearly (5 vials total)
  • Timing: Morning, on an empty stomach, at least 30 minutes before eating
  • Route: Subcutaneous (SQ) injection

GHRP-2 – 5mg / 10mg

Benefits & Mechanism:
GHRP-2 stimulates growth hormone (GH) release, which raises IGF-1 and improves endothelial responsiveness to NO. This results in enhanced vascular tone, circulation, and exercise recovery. GH-related signaling also protects nitric oxide from oxidative degradation.

Dosing & Protocol:

  • Reconstitution:
    • 5 mg vial → 2 ml
    • 10 mg vial → 2 ml
  • Daily Dose:
    • 5 mg → 166 mcg (10 units)
    • 10 mg → 333 mcg (10 units)
  • Cycle: 5 days on / 2 days off, 2.5–5 weeks
  • Timing: Based on personal preference; no strict time requirement
  • Route: Subcutaneous (SQ) injection

Ipamorelin – 2mg / 5mg

Benefits & Mechanism:
Like GHRP-2, Ipamorelin enhances GH secretion but with fewer side effects and a cleaner receptor profile. Increased GH/IGF-1 promotes NO-mediated vasodilation, helping with circulation, recovery, and muscle perfusion during training.

Dosing & Protocol:

  • Reconstitution:
    • 2 mg vial → 2 ml
    • 5 mg vial → 2.5 ml
  • Daily Dose:
    • 2 mg → 100–200 mcg (10–20 units)
    • 5 mg → 200 mcg (10 units)
  • Cycle: 5 days on / 2 days off, 4–5 weeks
  • Timing: Before bedtime on an empty stomach
  • Route: Subcutaneous (SQ) injection

Kisspeptin-10 – 5mg / 10mg

Benefits & Mechanism:
Kisspeptin regulates reproductive hormones via GnRH stimulation, increasing testosterone and estrogen. Both hormones enhance nitric oxide synthase activity in reproductive tissues, supporting erectile function, ovulation, and vascular health.

Dosing & Protocol:

  • Reconstitution:
    • 5 mg vial → 2 ml
    • 10 mg vial → 2 ml
  • Daily Dose:
    • 5 mg → 250 mcg (5 units)
    • 10 mg → 250 mcg (10 units)
  • Cycle: 3x per week (Mon/Wed/Fri) for 6.5 weeks
  • Timing: Morning on an empty stomach, at least 30 minutes before eating
  • Route: Subcutaneous (SQ) injection

MT-2 (Melanotan II) – 10mg

Benefits & Mechanism:
MT-2 activates melanocortin receptors, which stimulate NO release in penile and vaginal tissues, explaining its role in arousal and sexual function. It also improves skin resilience, indirectly protecting NO by reducing oxidative stress.

Dosing & Protocol:

  • Reconstitution: 3 ml bacteriostatic water
  • Daily Dose: 166 mcg (5 units)
  • Cycle: 1–3 times per week for up to 2 weeks, then reduce to once weekly
  • Timing: On an empty stomach or with a light meal
  • Route: Subcutaneous (SQ) injection

PT-141 – 10mg

Benefits & Mechanism:
PT-141 works through the central melanocortin system to trigger arousal but relies on NO-mediated vasodilation for erection and genital response. Unlike PDE-5 inhibitors, it does not act directly on blood vessels, but enhances NO release through neural signaling.

Dosing & Protocol:

  • Reconstitution: 2 ml bacteriostatic water
  • Daily Dose: 500 mcg (10 units) → up to 2 mg (40 units)
  • Cycle: 3x per week (Mon/Wed/Fri); start at 500 mcg and titrate upward
  • Timing: Based on personal preference
  • Route: Subcutaneous (SQ) injection

TB-500 – 2mg / 5mg

Benefits & Mechanism:
TB-500 enhances angiogenesis and endothelial repair via upregulation of VEGF and eNOS pathways. This improves microcirculation, tissue oxygenation, and overall NO bioavailability — critical for healing, vascular resilience, and performance.

Dosing & Protocol:

  • Reconstitution:
    • 2 mg vial → 2 ml
    • 5 mg vial → 2.5 ml
  • Daily Dose:
    • 2 mg → 100–200 mcg (10–20 units)
    • 5 mg → 200–400 mcg (10–20 units)
  • Cycle: 5 days on / 2 days off, 4–5 weeks
  • Timing: Morning, on an empty stomach, at least 30 minutes before eating
  • Route: Subcutaneous (SQ) injection

Potential Side Effects (from dosing guide)

  • Epithalon: Vivid dreams, mild headache, sleep changes (rare)
  • GHRP-2 / Ipamorelin: Water retention, appetite changes, flushing, tingling
  • Kisspeptin-10: Headache, flushing, hormonal changes
  • MT-2: Nausea, flushing, pigmentation changes (freckles/moles may darken), increased libido
  • PT-141: Nausea, headache, flushing, transient blood pressure changes
  • TB-500: Mild fatigue, injection-site redness, headache

Suggested Nitric Oxide (NO) Supporting Stacks

  • Cardiovascular health & circulation: Epithalon, TB-500, GHRP-2, Ipamorelin
  • Exercise performance & recovery: GHRP-2, Ipamorelin, TB-500
  • Sexual function & arousal: PT-141, MT-2, Kisspeptin-10

Notes

  • Choose your focus: Use GH secretagogues (GHRP-2, Ipamorelin) for performance/recovery, or PT-141/MT-2/Kisspeptin for sexual health.
  • Stacks: TB-500 + GH secretagogue can enhance tissue healing; PT-141 + Kisspeptin may synergize for reproductive function.
  • Always follow strict storage and reconstitution guidelines to maintain peptide integrity.

Disclaimer
This article is for educational purposes only and does not replace professional medical advice. Peptides may interact with medications and have contraindications. Always consult a qualified healthcare provider before starting, stopping, or combining peptide protocols.