Kisspeptin
Updated April 28, 2026
Primary Benefits:
- Stimulates natural production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)
- Supports natural testosterone synthesis
- May improve fertility in both men and women
- Helps restore HPTA (hypothalamic-pituitary-testicular axis) function
- Potential role in treating hypogonadism without suppression
Mechanism of Action:
Kisspeptin-10 is a synthetic form of a naturally occurring peptide that binds to the GPR54 receptor in the hypothalamus. This interaction stimulates the release of gonadotropin-releasing hormone (GnRH), which in turn triggers the pituitary to secrete LH and FSH. These hormones are essential for testosterone production and reproductive function, making Kisspeptin-10 a promising tool for fertility, hormone restoration, and post-cycle therapy (PCT) applications.
Dosing & Protocol
Subcutaneous (SQ) Injection:
- Reconstitution:
– 5 mg vial → 2.0 ml bacteriostatic water
– 10 mg vial → 2.0 ml bacteriostatic water - Daily Dose:
– 5 mg vial → 250 mcg (10 units)
– 10 mg vial → 250 mcg (5 units) - Cycle:
Monday, Wednesday, Friday
6.5 weeks - Timing:
Take in the morning on an empty stomach, at least 30 minutes before eating.
Potential Side Effects:
- Mild irritation or redness at injection site
- Temporary headache or dizziness
- Rare hormonal fluctuations or changes in libido
- No known long-term adverse effects in clinical use
Common Stacks:
- With HCG or Clomid: For comprehensive PCT support
- With Gonadorelin or L-Arginine: For amplified pituitary stimulation
- With GHK-Cu or BPC-157: For regenerative or post-cycle recovery support
Notes:
Kisspeptin-10 offers a non-suppressive route to restoring hormonal balance and boosting natural testosterone. Its role in activating GnRH makes it a potent tool for PCT, fertility treatment, and long-term hormone health. Always monitor hormonal markers during extended use and cycle responsibly.
Disclaimer:
The information provided in this article is for educational and informational purposes only and is not intended as medical advice. These statements have not been evaluated by the FDA or Health Canada. Peptides and other compounds discussed are intended for research purposes only and are not approved for human consumption unless prescribed by a licensed medical professional. Always consult your healthcare provider before starting any new protocol, supplement, or treatment.