Ipamorelin
Updated April 28, 2026
Primary Benefits:
- Stimulates natural growth hormone release
- Supports lean muscle development and fat burning
- Promotes deep, restorative sleep
- Aids in tissue recovery and cellular repair
- Minimal impact on appetite, prolactin, or cortisol
Mechanism of Action:
Ipamorelin is a selective GHRP (Growth Hormone Releasing Peptide) that binds to the ghrelin receptor (GHS-R1a), stimulating the pituitary to release GH in a pulsatile, physiologic pattern. It is highly targeted, lacking the appetite-stimulating or cortisol-raising effects seen with GHRP-2 and GHRP-6, making it ideal for those seeking recovery, fat loss, and GH support without hormonal side effects.
Dosing & Protocol
Subcutaneous (SQ) Injection:
- Reconstitution:
– 2 mg vial → 2.0 ml bacteriostatic water
– 5 mg vial → 2.5 ml bacteriostatic water - Daily Dose:
– 2 mg vial → 100–200 mcg (10–20 units)
– 5 mg vial → 100–200 mcg (5–10 units) - Cycle:
5 days on / 2 days off
6–12 weeks on, then 2–4 weeks off - Timing:
Before bedtime on an empty stomach.
Potential Side Effects:
- Temporary flushing or tingling
- Mild water retention
- Rare dizziness or nausea
- No appetite stimulation or cortisol spikes
Common Stacks:
- Typically paired with CJC-1295 (no DAC): Synergistic GH release
- With BPC-157 or TB-500: For injury recovery and muscle healing
- With 5-Amino-1MQ or AOD-9604: For body recomposition and metabolic support
Notes:
Ipamorelin is favored for its clean safety profile and targeted GH stimulation. It is well-suited for long-term anti-aging, recovery, and fat-loss protocols when used in combination with synergistic peptides or exercise regimens.
Disclaimer:
The information provided in this article is for educational and informational purposes only and is not intended as medical advice. These statements have not been evaluated by the FDA or Health Canada. Peptides and other compounds discussed are intended for research purposes only and are not approved for human consumption unless prescribed by a licensed medical professional. Always consult your healthcare provider before starting any new protocol, supplement, or treatment.