Ipamorelin + Tesamorelin Stack 5mg / 2mg

Primary Benefits

• Reduces visceral abdominal fat (especially stubborn midsection fat)

• Enhances natural growth hormone release without hormonal disruption

• Supports lean muscle retention and improved body composition

• Improves sleep quality and tissue recovery

• Boosts metabolic rate and energy regulation

• Synergistic action for fat-burning, healing, and long-term anti-aging

Mechanism of Action

This stack targets two distinct GH pathways to achieve powerful yet balanced results:

• Tesamorelin is a synthetic GHRH analog that stimulates the pituitary to release growth hormone, which in turn promotes lipolysis (fat breakdown), especially targeting visceral fat. It’s FDA-approved for HIV-related abdominal fat reduction, but its utility extends to general metabolic optimization.

• Ipamorelin is a gentle GHRP that stimulates GH secretion through the ghrelin receptor. It’s selective and clean — with no impact on appetite or cortisol — and is ideal for recovery, fat loss, and anti-aging.

Together, they deliver complementary GH pulses that promote lean body mass, reduce abdominal fat, and support metabolic health without overstimulation or hormonal imbalance.

Dosing & Protocol

Subcutaneous (SQ) Injection

Inject separately or together once tolerance is assessed. Administer into the lower abdomen.

Tesamorelin – 2mg Vial

• Reconstitution: 1.0 ml bacteriostatic water
   (= 1 mg per 50 units)

• Daily Dose: 1 mg (50 units)

• Cycle:
   6 days on / 1 day off
   4–24 weeks

• Timing: Before bed, at least 90 minutes after last meal

Ipamorelin – 5mg Vial

• Reconstitution: 2.5 ml bacteriostatic water
   (= 100–200 mcg per 5–10 units)

• Daily Dose: 100–200 mcg (5–10 units)

• Cycle:
   5 days on / 2 days off
   6–12 weeks on, 2–4 weeks off

• Timing: Take before bedtime with Tesamorelin on an empty stomach

Potential Side Effects

• Mild injection site irritation

• Water retention, bloating, or flushing (typically temporary)

• Occasional tingling in extremities or joint stiffness (rare)

• No appetite stimulation or cortisol spikes

• Elevated IGF-1 if overdosed on Tesamorelin

Who Is This Stack For?

• Individuals targeting stubborn abdominal or visceral fat

• Adults seeking safe GH stimulation for improved metabolic and recovery function

• Biohackers and professionals looking for a body recomposition stack with clinical backing

• Users experiencing GH decline symptoms: poor sleep, low energy, slow recovery

• Those aiming to improve metabolic rate, insulin sensitivity, and muscle tone

Notes

• Both peptides can be taken together at night in the same syringe

• Reconstituted vials should be refrigerated and used within 30–45 days

• Do not eat for 90–120 minutes prior to dosing for optimal effect

• Best results seen over 12–24 weeks, especially for visceral fat reduction

• Consider adding light resistance training and caloric moderation for maximum benefit

References

1. Falutz J, et al. Metabolic effects of a growth hormone-releasing factor in patients with HIV. N Engl J Med. 2007;357(23):2359-2370. PubMed
2. Falutz J, et al. Long-term safety and effects of tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulation. AIDS. 2008;22(14):1719-1728. PubMed
3. EGRIFTA SV (tesamorelin) for injection, prescribing information. Theratechnologies Inc. DailyMed, U.S. National Library of Medicine. PubMed
4. Drugs@FDA: EGRIFTA (tesamorelin acetate), BLA 022505, Theratechnologies; original approval 10 November 2010. U.S. Food and Drug Administration. PubMed
5. Raun K, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-561. PubMed

Disclaimer:
The information provided in this article is for educational and informational purposes only and is not intended as medical advice. These statements have not been evaluated by the FDA or Health Canada. Peptides and other compounds discussed are intended for research purposes only and are not approved for human consumption unless prescribed by a licensed medical professional. Always consult your healthcare provider before starting any new protocol, supplement, or treatment.